|
|
||||||||
1 Department of Fruit and Vegetable Science, Plant Science Building, Cornell University, Ithaca,
NY 14853.
Resveratrol is a phytoalexin found in grapes. Recent research had shown that orally administered resveratrol lowered lipid levels in the liver of rats. Wine had been shown to lower serum lipid levels in humans. The concentration of resveratrol was measured in selected wines using HPLC and spectrophotometry. Geographical origin, variety, growing methods, and winemaking procedures all seemed to affect resveratrol concentration. Analysis of wines indicated that resveratrol may be the active ingredient in wines causing reduction of serum lipids.
Key words: phenolics, stilbenes, resveratrol, Polyclar-AT
Submitted on July 2, 1991
This article has been cited by other articles:
![]() |
S. Kubota, T. Kurihara, H. Mochimaru, S. Satofuka, K. Noda, Y. Ozawa, Y. Oike, S. Ishida, and K. Tsubota Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-{kappa}B Activation Invest. Ophthalmol. Vis. Sci., July 1, 2009; 50(7): 3512 - 3519. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Szkudelski Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E901 - E907. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ulrich, S. M. Loitsch, O. Rau, A. von Knethen, B. Brune, M. Schubert-Zsilavecz, and J. M. Stein Peroxisome Proliferator-Activated Receptor {gamma} as a Molecular Target of Resveratrol-Induced Modulation of Polyamine Metabolism. Cancer Res., July 15, 2006; 66(14): 7348 - 7354. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-C. Su, L.-M. Hung, and J.-K. Chen Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1339 - E1346. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Yang and F. L. Meyskens Jr. Alterations in Activating Protein 1 Composition Correlate with Phenotypic Differentiation Changes Induced by Resveratrol in Human Melanoma Mol. Pharmacol., January 1, 2005; 67(1): 298 - 308. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Wolter, S. Ulrich, and J. Stein Molecular Mechanisms of the Chemopreventive Effects of Resveratrol and Its Analogs in Colorectal Cancer: Key Role of Polyamines? J. Nutr., December 1, 2004; 134(12): 3219 - 3222. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. C. Ziegler, L. Rainwater, J. Whelan, and M. F. McEntee Dietary Resveratrol Does Not Affect Intestinal Tumorigenesis in ApcMin/+ Mice J. Nutr., January 1, 2004; 134(1): 5 - 10. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. D. Ragione, V. Cucciolla, V. Criniti, S. Indaco, A. Borriello, and V. Zappia p21Cip1 Gene Expression Is Modulated by Egr1: A NOVEL REGULATORY MECHANISM INVOLVED IN THE RESVERATROL ANTIPROLIFERATIVE EFFECT J. Biol. Chem., June 20, 2003; 278(26): 23360 - 23368. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Boscolo, A. d. Signore, E. Sabbioni, M. Di Gioacchino, L. Di Giampaolo, M. Reale, P. Conti, R. Paganelli, and M. Giaccio Effects of Resveratrol on Lymphocyte Proliferation and Cytokine Release Ann. Clin. Lab. Sci., April 1, 2003; 33(2): 226 - 231. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-F. Marier, P. Vachon, A. Gritsas, J. Zhang, J.-P. Moreau, and M. P. Ducharme Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model J. Pharmacol. Exp. Ther., July 1, 2002; 302(1): 369 - 373. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Orallo, E. Alvarez, M. Camina, J. M. Leiro, E. Gomez, and P. Fernandez The Possible Implication of trans-Resveratrol in the Cardioprotective Effects of Long-Term Moderate Wine Consumption Mol. Pharmacol., February 1, 2002; 61(2): 294 - 302. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Juan, M. P. Vinardell, and J. M. Planas The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful J. Nutr., February 1, 2002; 132(2): 257 - 260. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Gusman, H. Malonne, and G. Atassi A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol Carcinogenesis, August 1, 2001; 22(8): 1111 - 1117. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. H. M. de Vries, P. C. H. Hollman, I. van Amersfoort, M. R. Olthof, and M. B. Katan Red Wine Is a Poor Source of Bioavailable Flavonols in Men J. Nutr., March 1, 2001; 131(3): 745 - 748. [Abstract] [Full Text] |
||||
![]() |
D. P. Malinowski and D. P. Belesky Adaptations of Endophyte-Infected Cool-Season Grasses to Environmental Stresses: Mechanisms of Drought and Mineral Stress Tolerance Crop Sci., July 1, 2000; 40(4): 923 - 940. [Abstract] [Full Text] |
||||
![]() |
R. F. Casper, M. Quesne, I. M. Rogers, T. Shirota, A. Jolivet, E. Milgrom, and J.-F. Savouret Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity Mol. Pharmacol., October 1, 1999; 56(4): 784 - 790. [Abstract] [Full Text] |
||||
![]() |
J. H. Stein, J. G. Keevil, D. A. Wiebe, S. Aeschlimann, and J. D. Folts Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease Circulation, September 7, 1999; 100(10): 1050 - 1055. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. D. Gehm, J. M. McAndrews, P.-Y. Chien, and J. L. Jameson Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor PNAS, December 9, 1997; 94(25): 14138 - 14143. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. B Rimm, A. Klatsky, D. Grobbee, and M. J Stampfer Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? BMJ, March 23, 1996; 312(7033): 731 - 736. [Abstract] [Full Text] |
||||
![]() |
L. A. Stivala, M. Savio, F. Carafoli, P. Perucca, L. Bianchi, G. Maga, L. Forti, U. M. Pagnoni, A. Albini, E. Prosperi, et al. Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol J. Biol. Chem., June 15, 2001; 276(25): 22586 - 22594. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |