@article {Fagan163, author = {Gian L. Fagan and R. E. Kepner and A. D. Webb}, title = {Biosynthesis of Certain Gamma-Substituted-Gamma-Butyrolactones Present in Film Sherries}, volume = {32}, number = {2}, pages = {163--167}, year = {1981}, doi = {10.5344/ajev.1981.32.2.163}, publisher = {American Journal of Enology and Viticulture}, abstract = {Ethyl 4-oxobutyrate-2-14C added to a simulated sherry under an actively growing film of S. fermentati yielded radioactive gamma-butyrolactone, diethyl succinate, ethyl 4-oxobutyrate diethyl acetal, an unidentified ester, and 4-hydroxy-5-ketohexanoic acid gamma-lactone, thus confirming the pathways proposed earlier for their formation. When unlabeled ethyl 4-oxobutyrate was used in similar experiments, the same compounds and 4,5-dihydroxyhexanoic acid gamma-lactone had their concentrations enhanced. 4-Hydroxy-5-ketohexanoic acid gamma-lactone isolated from the latter experiment was optically active (+) and showed a specific rotation vs. wavelength "plain curve."}, issn = {0002-9254}, URL = {https://www.ajevonline.org/content/32/2/163}, eprint = {https://www.ajevonline.org/content/32/2/163.full.pdf}, journal = {American Journal of Enology and Viticulture} }