PT  - JOURNAL ARTICLE
AU  - Gian L. Fagan
AU  - R. E. Kepner
AU  - A. D. Webb
TI  - Biosynthesis of Certain Gamma-Substituted-Gamma-Butyrolactones Present in Film Sherries
AID  - 10.5344/ajev.1981.32.2.163
DP  - 1981 Jan 01
TA  - American Journal of Enology and Viticulture
PG  - 163--167
VI  - 32
IP  - 2
4099  - http://www.ajevonline.org/content/32/2/163.short
4100  - http://www.ajevonline.org/content/32/2/163.full
SO  - Am J Enol Vitic.1981 Jan 01; 32
AB  - Ethyl 4-oxobutyrate-2-14C added to a simulated sherry under an actively growing film of S. fermentati yielded radioactive gamma-butyrolactone, diethyl succinate, ethyl 4-oxobutyrate diethyl acetal, an unidentified ester, and 4-hydroxy-5-ketohexanoic acid gamma-lactone, thus confirming the pathways proposed earlier for their formation. When unlabeled ethyl 4-oxobutyrate was used in similar experiments, the same compounds and 4,5-dihydroxyhexanoic acid gamma-lactone had their concentrations enhanced. 4-Hydroxy-5-ketohexanoic acid gamma-lactone isolated from the latter experiment was optically active (+) and showed a specific rotation vs. wavelength "plain curve."