RT Journal Article
SR Electronic
T1 Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation
JF American Journal of Enology and Viticulture
JO Am. J. Enol. Vitic.
FD American Society for Enology and Viticulture
SP 146
OP 151
DO 10.5344/ajev.2012.11131
VO 64
IS 1
A1 Takeshi Sugiyama
A1 Masanori Kitamura
A1 Kanji Sugita
A1 Tohru Okuda
A1 Masashi Hisamoto
A1 Atsuhito Nakao
YR 2013
UL http://www.ajevonline.org/content/64/1/146.abstract
AB The aryl hydrocarbon receptor (AhR) pathway is now considered an important pharmacological target for many human diseases. This study examined the effects of grape seed extract (GSE) obtained from the Koshu grape variety on AhR activity. The Koshu-derived GSE inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation in vivo and in vitro. These results suggest that Koshu GSE has an antagonistic effect on TCDD-induced AhR activation. Furthermore, gavage administration of TCDD resulted in the elevation of liver function, but administration of Koshu GSE together with TCDD did not elevate serum aspartate aminotransaminase (AST) and alanine transaminase (ALT) levels. These results suggest that Koshu GSE may have the potential to prevent liver disorders.