Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

doi:10.1016/0140-6736(93)90206-V

The Lancet

Volume 341, Issue 8843, 20 February 1993, Pages 454-457

https://doi.org/10.1016/0140-6736(93)90206-V Get rights and content

Abstract

The "French paradox" (apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis) has been attributed to the regular drinking of red wine. However, the alcohol content of wine may not be the sole explanation for this protection. Red wine also contains phenolic compounds, and the antioxidant properties of these may have an important role. In in-vitro studies with phenolic substances in red wine and normal human low-density lipoprotein (LDL) we found that red wine inhibits the coppercatalysed oxidation of LDL. Wine diluted 1000-fold containing 10 μmol/L total phenolics inhibited LDL oxidation significantly more than α-tocopherol. Our findings show that the non-alcoholic components of red wine have potent antioxidant properties toward oxidation of human LDL.

References (31)

Je Kinsella et al.
Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular diseases—possible mechanisms
Am J Clin Nutr
(1990)
S Renaud et al.
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Lancet
(1992)
H Esterbauer et al.
The role of lipid peroxidation and antioxidants in oxidative modification of low density lipoproteins
Free Radical Biol Med
(1992)
I Jialal et al.
Physiological levels of ascorbate inhibit the oxidative modification of low density lipoproteins
Atherosclerosis
(1990)
Cv De Whalley et al.
Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages
Biochem Pharmacol
(1990)
A Nègre-Salvayre et al.
Quercetin prevents the cytotoxicity of oxidized low density lipoproteins in lymphoid cell lines
Free Rad Biol Med
(1992)
J Kanner et al.
Initiation of membranal lipid peroxidation by activated metmyoglobin and methemoglobin
Arch Biochem Biophys
(1985)
J Torel et al.
Antioxidant activity of flavonoids and reactivity with peroxy radicals
Phytochemistry
(1986)
NP Das
Studies on flavonoid metabolism: absorption and metabolism of (+)-catechin in man
Biochem Pharmacol
(1971)
National Research Council Committee on Diet and Health
Diet and health: implications for reducing chronic disease risk
(1989)

SM Grundy

Cholesterol and coronary heart disease: a new era

JAMA

(1986)

Nutritional Committee , American Heart Association

Dietary guidelines for healthy American adults

Circulation

(1988)

Eb Rimm et al.

Prospective study of alcohol consumption and risk of coronary heart disease in men

Lancet

(1991)

Nb Lazarus et al.

Change in alcohol consumption and risk of death from all causes and from ischaemic heart disease

BMJ

(1991)

La Friedman et al.

Coronary heart disease mortality and alcohol consumption in Framingham

Am J Epidemiol

(1986)

Cited by (1639)

Non-invasive caffeinated-nanovesicles as adipocytes-targeted therapy for cellulite and localized fats
2024, International Journal of Pharmaceutics: X
Caffeine (CAF) is a non-selective adenosine A1 receptor antagonist which predominates in fat cells. When CAF binds to adenosine receptors, it increases cyclic adenosine monophosphate; inhibiting adipogenesis and inducing fat lipolysis. Resveratrol (RSV) is an antioxidant polyphenol possessing different anti-obesity mechanisms. Topical application of both hydrophilic CAF and lipophilic RSV is limited.
This study aimed to develop novel caffeinated-resveratrol bilosomes (CRB) and caffeine-bilosomes (CB) that could non-invasively target and deposit in fat cells. RSV bilosomes (RB) were prepared as a non-targeted system for comparison. CRB showed nanosize (364.1 nm ±6.5 nm) and high entrapment for both active compounds. Rats treated topically with CRB revealed a significant decrease (P = 0.039) in body weight. Histological analysis of the excised skin demonstrated a reduction in the subcutaneous fatty layer thickness and a decrease in the size of connective tissue-imbedded fat cells. Kidney histological examination of RB-treated rats showed subcapsular tubular epithelial cells with cytoplasmic vacuolation. This reflects a systemic effect of RSV from the non-targeted RB compared to CRB, which had a targeting effect on the adipose tissue. In conclusion, CAF in CRB significantly enhanced RSV deposition in adipose tissue and assisted its local-acting effect for managing obesity and cellulite.
Prediction of total phenolic acids contained in plant extracts by PLS-ATR-FTIR
2022, South African Journal of Botany
Phenols found in plants are becoming increasingly important. Hydroxybenzoic and hydroxycinnamic acids are the predominant phenolic acids. The main objective of this study is to exploit the experiments carried out for the specific quantification of phenolic acids present in plant extracts by PLS-ATR-FTIR to the determination of total phenolic acids (TPA). Individual phenolic acids were measured between 1566 and 563 cm⁻¹ whereas the common band representative of the total phenolic acids was selected between 1737 and 1624 cm⁻¹. To pass from the quantification of individual-specific phenolic acids to the deduction of the content of total phenolic acids, present in extracts of aromatic plants by PLS-ATR-FTIR, we considered a simple calculation of the concentration of total phenols as being the sum of the concentrations of standard phenols present in the mixtures and the selection of a spectral region common to all the phenolic acids considered. The study developed provides a simple, fast, and precise procedure for the individual simultaneous determination of six phenolic acids (salicylic acid, p-hydroxybenzoic acid, vanillic acid, gallic acid, trans-cinnamic acid, and eugenol) and the estimation of the total phenolic acids present in eighteen extracts of aromatic plants, with the additional advantage of the possibility of examining the plant extracts with a simple plant material extraction by maceration with ethanol which is classified as a green solvent thus providing a green methodology.
Novel dermal nanobilosomes with promising browning effect of adipose tissue for management of obesity
2022, Journal of Drug Delivery Science and Technology
Obesity is a medical problem that increases the risk of various diseases. Besides, obese people sometimes feel discrimination which results in social isolation and severe depression. Therefore, the management of obesity and localized fats gains a great interest.
The aim of this study is to fabricate topical nanobilosomal preparation that mimics the action of subcutaneous lipolysis injections with the advantage of non-invasiveness. Moreover, resveratrol (RSV) was loaded for the first time on bilosomal nanovesicles for the browning of white adipose tissue (WAT) via topical application. The prepared RSV-loaded bilosomes showed good quality attributes regarding particle size (255 ± 6.16 nm), % entrapment efficiency (94.58 ± 2.81%), and zeta potential (−51.31 ± 3.72). Moreover, RSV-loaded bilosomes showed 2.6 fold increase in drug release compared to resveratrol suspension using dialysis tube technique. The in-vivo study using induced obesity Wistar rats revealed that rats treated with RSV-loaded bilosomal gel formulations demonstrated detectable body weight loss (−19.7%) from the total weight, and a decrease in their abdominal circumference compared to the positive control group. Moreover, upon histological examination of isolated subcutaneous fats, a significant decrease in the average size and a 1.4-fold increase in the average total number of subcutaneous fats deposits were observed. To conclude, RSV-loaded bilosomes as novel topical nanotherapy possessed a promising effect in managing obesity and browning of WAT.
Olive, apple, and grape pomaces with antioxidant and anti-inflammatory bioactivities for functional foods
2022, Functional Foods and their Implications for Health Promotion
The well-established health benefits of fruits, vegetables, and their food products, have increased dramatically their demand, which however has led to a subsequent increase in processing byproducts. During agriculture processing for producing such plant-derived foods, oils, and beverages, huge amounts of byproducts are obtained, which usually are treated as wastes with costly waste management, while some of them are also used as animal feeds and/or fertilizers. Recent research has shown that considerable amounts of valuable bioactive compounds usually remain within these byproducts, and thus instead of disposing them as part of the food wastes, their extraction, recovery, and valorization can provide another source of functional ingredients for the development of novel products with improved health benefits. Within this chapter, characteristic examples of such functional byproducts are thoroughly reviewed, such as the olive pomace, apple pomace, and grape pomace, which are derived from processing during the production of olive oil, wine, and apple juice, cider, and vinegar, respectively. The composition, nutritional value, and health benefits of these pomaces and of their valuable compounds are also outlined, such as several bioactive lipids, phenolics, fiber, and other valuable compounds with potent antioxidant, antiinflammatory, and antithrombotic properties. Specific paradigms are also given for the valorization of these pomaces and of their bioactive in the industrial setting for the production of functional foods and nutraceuticals, or even as health-promoting natural pharmaceutical ingredients or biofunctional ingredients for the production of innovative enriched foods against the risk for several chronic diseases, and especially against inflammation-related disorders. Emphasis is also given to the overall health benefits of the functional end products with similar or even improved sensory characteristics and high acceptance by the consumers.
Evolution of phenolic profile of white wines treated with enzymes
2021, Food Chemistry
The aim of this study is to monitor the evolution of the principal phenolic compounds throughout the fermentation stage of white wines treated with different enzymes. The effect of five commercial enzymes on the evolution of the phenolic profile during the alcoholic fermentation of white wines obtained from Fetească regală and Sauvignon blanc varieties was evaluated. Physicochemical properties of resulted wine samples have been analyzed according to OIV standards and regulations. The evolution of the principal phenolic compounds was carried out using HPLC method. Enzymatic treatments did not significantly affect the physicochemical composition of the obtained wines. The analyzed samples showed different variations on the phenolic compound content, depending on the type of added enzyme and grape variety. The statistical analysis confirms that enzymes significantly contributed to the enrichment of the wines with phenolic compounds, especially with p-coumaric, gentisic, caftaric, and protocatechuic acids.
Antioxidant peptides, the guardian of life from oxidative stress
2024, Medicinal Research Reviews

View all citing articles on Scopus

View full text

ARTICLESInhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

Abstract

Am J Clin Nutr

Lancet

Free Radical Biol Med

Atherosclerosis

Biochem Pharmacol

Free Rad Biol Med

Arch Biochem Biophys

Phytochemistry

Biochem Pharmacol

Diet and health: implications for reducing chronic disease risk

Cholesterol and coronary heart disease: a new era

JAMA

Dietary guidelines for healthy American adults

Circulation

Prospective study of alcohol consumption and risk of coronary heart disease in men

Lancet

Change in alcohol consumption and risk of death from all causes and from ischaemic heart disease

BMJ

Coronary heart disease mortality and alcohol consumption in Framingham

Am J Epidemiol

ARTICLES
Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine