Determination of 9-hydroxyellipticine by redox colorimetry

J Pharm Biomed Anal. 1992 Jun;10(6):427-36. doi: 10.1016/0731-7085(92)80061-q.

Abstract

The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / analysis*
  • Antineoplastic Agents / chemistry
  • Chromatography, Thin Layer / methods
  • Colorimetry / methods
  • Ellipticines / analysis*
  • Ellipticines / chemistry
  • Oxidation-Reduction

Substances

  • Antineoplastic Agents
  • Ellipticines
  • 9-hydroxyellipticine