User profiles for B. Gini
Beatrice Gini, Ph.D.University of California at San Francisco (UCSF) Verified email at ucsf.edu Cited by 4131 |
A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
Chemotherapy and molecularly targeted approaches represent two very different modes of
cancer treatment and each is associated with unique benefits and limitations. Both types of …
cancer treatment and each is associated with unique benefits and limitations. Both types of …
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
DA Nathanson, B Gini, J Mottahedeh, K Visnyei… - Science, 2014 - science.org
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …
Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis
…, B Rossi, S Angiari, L Calderan, E Anghileri, B Gini… - Stem …, 2009 - academic.oup.com
… (B) Total draining lymph node cells were isolated from mice transplanted with ASC in the
pre-clinical phase of the disease and from control mice. Ex vivo analysis of T-cell proliferation of …
pre-clinical phase of the disease and from control mice. Ex vivo analysis of T-cell proliferation of …
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
A widespread approach to modern cancer therapy is to identify a single oncogenic driver
gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-…
gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-…
Oncogenic EGFR signaling activates an mTORC2–NF-κB pathway that promotes chemotherapy resistance
… B, immunoblot analysis of LN229 GBM cells in which EGFRvIII was placed under a
doxycycline-regulatable promoter. C, representative immunohistochemical images demonstrating p-…
doxycycline-regulatable promoter. C, representative immunohistochemical images demonstrating p-…
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR–dependent pathway
…, S Zhu, I Babic, K Tanaka, J Dang, A Iwanami, B Gini… - Cancer discovery, 2011 - AACR
… B, quantitative analysis of LDLR expression in GBM versus adjacent normal tissues. C,
correlation analysis between LDLR expression and p-EGFR, p-Akt, or SREBP-1 in 140 GBM …
correlation analysis between LDLR expression and p-EGFR, p-Akt, or SREBP-1 in 140 GBM …
[PDF][PDF] mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc
… of acetylated FoxO1 and FoxO3 (Figure 2B). Rictor knockdown also increased the formation
… Conversely, Rictor overexpression increased the level of FoxO acetylation (Figure S2B) and …
… Conversely, Rictor overexpression increased the level of FoxO acetylation (Figure S2B) and …
[HTML][HTML] The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
… In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (… A3B
and revealed therapy-induced activation of nuclear factor kappa B (NF-κB) as an inducer of A3B …
and revealed therapy-induced activation of nuclear factor kappa B (NF-κB) as an inducer of A3B …
[HTML][HTML] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
… (B) Glutamine and glutamate levels in MRS studies for tumors and contralateral normal
brain regions in 12 GBM patients. The relative level of glutamine and glutamate was calculated …
brain regions in 12 GBM patients. The relative level of glutamine and glutamate was calculated …
[PDF][PDF] Single-cell phosphoproteomics resolves adaptive signaling dynamics and informs targeted combination therapy in glioblastoma
… In Figure 6B we plot the correlations of the assayed proteins, … constitute mode 1 of Figure
4B lie principally along PC1, as … two signaling modes (Figure 4B) resolved in the SCBC data …
4B lie principally along PC1, as … two signaling modes (Figure 4B) resolved in the SCBC data …