A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway
…, J Ayté, MB Toledano, E Hidalgo - Proceedings of the …, 2005 - National Acad Sciences
The Schizosaccharomyces pombe transcription factor Pap1 regulates antioxidant-gene
transcription in response to H 2 O 2 . Pap1 activation occurs only at low, but not elevated, H 2 O …
transcription in response to H 2 O 2 . Pap1 activation occurs only at low, but not elevated, H 2 O …
An iron‐sulfur center essential for transcriptional activation by the redox‐sensing SoxR protein.
E Hidalgo, B Demple - The EMBO journal, 1994 - embopress.org
The soxRS oxidative stress regulon of Escherichia coli is triggered by superoxide (O2.‐)
generating agents or by nitric oxide through two consecutive steps of gene activation. SoxR …
generating agents or by nitric oxide through two consecutive steps of gene activation. SoxR …
[HTML][HTML] The redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor
SoxR protein is a redox-responsive transcription factor that governs a regulon of oxidative
stress and antibiotic resistance genes in Escherichia coli. Purified SoxR contains oxidized [2Fe…
stress and antibiotic resistance genes in Escherichia coli. Purified SoxR contains oxidized [2Fe…
Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration
…, EA Castillo, N Jones, J Ayté, E Hidalgo - Molecular …, 2004 - Wiley Online Library
The transcription factor Pap1 and the MAP kinase Sty1 are key regulators of hydrogen
peroxide‐induced responses in Schizosaccharomyces pombe. Pap1 can be activated quickly at …
peroxide‐induced responses in Schizosaccharomyces pombe. Pap1 can be activated quickly at …
[PDF][PDF] Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle
…, S García-Santamarina, J Ayte, E Hidalgo - Cell reports, 2013 - cell.com
In fission yeast, the transcription factor Pap1 undergoes H 2 O 2 -dependent oxidation that
promotes its nuclear accumulation and the activation of an antioxidant gene program. …
promotes its nuclear accumulation and the activation of an antioxidant gene program. …
Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene
T Nunoshiba, E Hidalgo, CF Amabile Cuevas… - Journal of …, 1992 - Am Soc Microbiol
Escherichia coli responds to the redox stress imposed by superoxide-generating agents such
as paraquat by activating the synthesis of as many as 80 polypeptides. Expression of a key …
as paraquat by activating the synthesis of as many as 80 polypeptides. Expression of a key …
[HTML][HTML] Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription
E Hidalgo, JM Bollinger Jr, TM Bradley… - Journal of Biological …, 1995 - Elsevier
SoxR protein of Escherichia coli is activated by superoxide-generating agents or nitric oxide
as a powerful transcription activator of the soxS gene, whose product activates ∼10 other …
as a powerful transcription activator of the soxS gene, whose product activates ∼10 other …
Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction
S García-Santamarina, S Boronat, E Hidalgo - Biochemistry, 2014 - ACS Publications
Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine
oxidation is a major mechanism for intracellular signaling. Understanding why some cysteine …
oxidation is a major mechanism for intracellular signaling. Understanding why some cysteine …
[HTML][HTML] Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs
…, M Rodriguez-Gabriel, J Ayte, S Leidel, E Hidalgo - PLoS …, 2013 - journals.plos.org
The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as
an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display …
an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display …
Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway
…, N Gabrielli, AP Vivancos, J Ayté, E Hidalgo - The EMBO …, 2010 - embopress.org
Either calorie restriction, loss‐of‐function of the nutrient‐dependent PKA or TOR/SCH9
pathways, or activation of stress defences improves longevity in different eukaryotes. However, …
pathways, or activation of stress defences improves longevity in different eukaryotes. However, …