Clinical pharmacology and mechanism of action of zonisamide

V Biton - Clinical neuropharmacology, 2007 - journals.lww.com
Antiepileptic drugs (AEDs) suppress seizures by selectively modifying the excitability of
neurons and blocking seizure firing with minimal disturbance of nonepileptic activity. All AEDs …

The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle

S Biton, A Barzilai, Y Shiloh - DNA repair, 2008 - Elsevier
Human genomic instability syndromes affect the nervous system to different degrees of
severity, attesting to the vulnerability of the CNS to perturbations of genomic integrity and the …

Effect of antiepileptic drugs on bodyweight: overview and clinical implications for the treatment of epilepsy

V Biton - CNS drugs, 2003 - Springer
The potential of specific antiepileptic drugs (AEDs) to cause clinically significant changes in
bodyweight is a key consideration in the management of epilepsy; changes in weight can …

A single-cell survey of the small intestinal epithelium

AL Haber, M Biton, N Rogel, RH Herbst, K Shekhar… - Nature, 2017 - nature.com
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial …

[HTML][HTML] Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis

…, MN Katz, T Korem, N Zmora, Y Kuperman, I Biton… - Cell, 2014 - cell.com
All domains of life feature diverse molecular clock machineries that synchronize physiological
processes to diurnal environmental fluctuations. However, no mechanisms are known to …

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

DT Montoro, AL Haber, M Biton, V Vinarsky, B Lin… - Nature, 2018 - nature.com
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-…

[PDF][PDF] Intra-and inter-cellular rewiring of the human colon during ulcerative colitis

CS Smillie, M Biton, J Ordovas-Montanes, KM Sullivan… - Cell, 2019 - cell.com
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC).
To understand their cell type specificities and pathways of action, we generate an atlas of …

Host immune system gene targeting by a viral miRNA

…, N Elefant, A Zimmermann, DG Wolf, N Saleh, M Biton… - Science, 2007 - science.org
Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses.
However, their biological roles are mostly unknown. We developed an algorithm for the …

[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer

…, A Kanodia, EZ Todres, J Jané-Valbuena, M Biton… - Cell, 2021 - cell.com
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …

Widespread occurrence of antisense transcription in the human genome

…, O Goldstein, A Shoshan, A Diber, S Biton… - Nature …, 2003 - nature.com
An increasing number of eukaryotic genes are being found to have naturally occurring antisense
transcripts. Here we study the extent of antisense transcription in the human genome by …