[HTML][HTML] QuPath: Open source software for digital pathology image analysis
…, RT Gray, LJ Murray, HG Coleman, JA James… - Scientific reports, 2017 - nature.com
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly,
extensible, open-source solution for digital pathology and whole slide image analysis. …
extensible, open-source solution for digital pathology and whole slide image analysis. …
[HTML][HTML] Development of autoantibodies before the clinical onset of systemic lupus erythematosus
…, RH Scofield, GJ Dennis, JA James… - … England Journal of …, 2003 - Mass Medical Soc
Background Although much is known about the natural history of systemic lupus erythematosus
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …
Frequent amyloid deposition without significant cognitive impairment among the elderly
Objective To characterize the prevalence of amyloid deposition in a clinically unimpaired
elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission …
elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission …
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
[HTML][HTML] New-onset IgG autoantibodies in hospitalized patients with COVID-19
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune
features and autoantibody production. Here we develop three protein arrays to measure IgG …
features and autoantibody production. Here we develop three protein arrays to measure IgG …
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
JA James, KM Kaufman, AD Farris… - The Journal of …, 1997 - Am Soc Clin Investig
… (JA James and JB Harley, unpublished data). Among these differences is the tendency for
normal sera to bind the glycine–alanine repeat of EBNA-1 while lupus sera do not generally …
normal sera to bind the glycine–alanine repeat of EBNA-1 while lupus sera do not generally …
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …
Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure
JA James, BR Neas, KL Moser, T Hall… - … : Official Journal of …, 2001 - Wiley Online Library
Objective The possible molecular mimicry of the Epstein‐Barr virus (EBV) peptide PPPGRRP
by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is consistent with the …
by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is consistent with the …
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve
both genetic and environmental factors. To identify environmental agents that could potentially …
both genetic and environmental factors. To identify environmental agents that could potentially …
Amyloid imaging in mild cognitive impairment subtypes
Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine
the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (…
the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (…