… H. Wilson. 1986. Formation of deletions after initiation of simian virus 40 replication: influence
… Wilson. 1984. How damaged is the biologically active subpopulation of transfected DNA? …

Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of
gene structure and function, and in understanding chromosome dynamics. It also offers a …

purpose. Early visual defects in degenerative diseases such as retinitis pigmentosa (RP)
may arise from phased remodeling of the neural retina. The authors sought to explore the …

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic
instability has been shown to increase during aging, suggesting an aberrant function of DNA …

In mammalian cells, chromosomal double-strand breaks are efficiently repaired, yet little is
known about the relative contributions of homologous recombination and illegitimate …

The primary mechanism of nonhomologous recombination in transfected DNA involves
breakage followed by end joining. To probe the joining step in more detail, linear simian virus 40 …

Transcription stimulates the genetic instability of trinucleotide repeat sequences. However,
the mechanisms leading to transcription-dependent repeat length variation are unclear. We …

Induced transcription through CAG repeats in human cells increases repeat contraction ∼15-fold
in both confluent and proliferating cells. Repeats are stabilized against contraction by …

Oligonucleotides offer enormous potential for manipulating gene function in cells and, as
such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form …

Bardet–Biedl syndrome (BBS) is an oligogenic syndrome whose manifestations include retinal
degeneration, renal abnormalities, obesity and polydactylia. Evidence suggests that the …