The clinical events resulting from atherosclerosis are directly related to the oxidation of lipids
in LDLs that become trapped in the extracellular matrix of the subendothelial space. These …

Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …

… 14 Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edwards PA. Malondialdehyde
alteration of low density lipoproteins leads to cholesteryl ester accumulation in human …

LXRα is a nuclear receptor that has previously been shown to regulate the metabolic
conversion of cholesterol to bile acids. Here we define a role for this transcription factor in the …

Previous work has implicated PPARγ in the regulation of CD36 expression and macrophage
uptake of oxidized LDL (oxLDL). We provide evidence here that in addition to lipid uptake, …

Glutaraldehyde treatment of 125 I-labeled low density lipoprotein ( 125 I-native-LDL)
produced a modified LDL ( 125 I-glut-LDL) with a molecular weight of 10 × 10 6 or more. …

The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of
several conjugated compounds across the apical membrane of the hepatocyte into the bile …

Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol
homeostasis. Here we demonstrate that FXR also regulates glucose metabolism. Activation …

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid
homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL. …

Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis.
We now examine genetic, dietary, and hormonal factors regulating TMAO levels. We …