… TLS occurs when the amount of potassium, phosphorus, nucleic acids and cytokines
released from cell lysis exceeds the body’s homeostatic mechanisms to deal with them. Renal …

Clinicians, especially physicians in training, often work long hours and get inadequate sleep.
The implications of fatigue among clinicians for the quality of medical care have not been …

High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m 2 , is used to
treat a range of adult and childhood cancers. Although HDMTX is safely administered to most …

Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and
discussed the design of randomized clinical trials. Part II now describes efficient methods of …

This review is written from the perspective of scientists working in lignocellulose bioconversion
in a developing country and the aim of this review is to remind ourselves and other …

Background The mechanisms by which hypertension causes vascular events are unclear.
Guidelines for diagnosis and treatment focus only on underlying mean blood pressure. We …

The Medical Research Council has for some years encouraged collaborative clinical trials in
leukaemia and other cancers, reporting the results in the medical literature. One unreported …

An optical metamaterial is a composite in which subwavelength features, rather than the
constituent materials, control the macroscopic electromagnetic properties of the material. …

Background Prophylactic cranial irradiation has been a standard treatment in children with
acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) …

Background The incidence of stroke is predicted to rise because of the rapidly ageing
population. However, over the past two decades, findings of randomised trials have identified …