Partitioning of lipid precursors between membranes and storage is crucial for cell growth, and
its disruption underlies pathologies such as cancer, obesity, and type 2 diabetes. However…

The biogenesis of autophagosomes depends on the conjugation of Atg8-like proteins with
phosphatidylethanolamine. Atg8 processing by the cysteine protease Atg4 is required for its …

Deconjugation of the Atg8/ LC 3 protein family members from phosphatidylethanolamine ( PE
) by Atg4 proteases is essential for autophagy progression, but how this event is regulated …

Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human
diseases. In α 1 -antitrypsin deficiency, the pathogenic Z variant aberrantly assembles into …

Immobilized cells of Schizosaccharomyces pombe yeast were used for total or partial
deacidification of grape must. All experiments were carried out using dry immobilized yeast cells …

Cullin-RING ligases (CRLs) control key cellular processes by promoting ubiquitylation of a
multitude of soluble cytosolic and nuclear proteins. Subsets of CRL complexes are recruited …

The development of nanoparticle (NP)-based drug carriers has presented an exciting
opportunity to address challenges in oncology. Among the 100,000 available possibilities, …

Background Alveolar epithelial cell dysfunction plays an important role in the pathogenesis
of idiopathic pulmonary fibrosis (IPF), but remains incompletely understood. Some …

Sphingolipids play an essential role in the functioning of the secretory pathway in eukaryotic
organisms. Their importance in the functional organization of plant cells has not been …

Background Temporomandibular joint (TMJ) disorders show inflammatory components,
heavily impacting on quality of life. Strontium ranelate has previously shown anti-inflammatory …