Structure-Activity Study of the Inhibition of Microtubule Assembly in Vitro by Podophyllotoxin and Its Congeners

JD Loike, CF Brewer, H Sternlicht, WJ Gensler… - Cancer Research, 1978 - AACR
Gensler, and Susan B. Horwi@5 … and WJGensler. … Gensler, WJ, and Gatsonis, CD
The Podophyllin-Picropodophyllo toxin Equilibrium. J. Org. …

Compounds Related to Podophyllotoxin. XII. Podophyllotoxone, Picropodophyllone and Dehydropodophyllotoxin1

WJ Gensler, F Johnson, ADB Sloan - Journal of the American …, 1960 - ACS Publications
Manganese dioxide converts podophyllotoxin and picropodophyllin to the corresponding
ketones, podophyllotoxone and picropodophyllone. The ketones with sodium borohydride give …

Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly

…, SB Horwitz, H Sternlicht, WJ Gensler - Journal of Medicinal …, 1979 - ACS Publications
Gensler and Gatsonis26 have suggested that the small residual activity of picropodophyllotoxin
could be due to a small amount of podophyllotoxin in thesample that could arise from …

The Synthesis of Isoquinolines by the P omeranz‐F ritsch Reaction

WJ Gensler - Organic Reactions, 2004 - Wiley Online Library
Acid‐catalyzed cyclization of benzalaminoacetal results in the formation of the isoquinoline
nucleus. This reaction, first reported by Pomeranz and Fritsch, has been used in the …

Synthesis of Podophyllotoxin1,2

WJ Gensler, CD Gatsonis - The Journal of organic chemistry, 1966 - ACS Publications
Method A.“Total-Conversion” Method. Ethyl (a-Carbethoxy-/3-m-chloroanilino) acrylate.—The
above reaction product, or crystalline bis (m-chlorophenyl) formamidine base (53 g, 0.2 …

Nonenolizable podophyllotoxin derivatives

WJ Gensler, CD Murthy… - Journal of Medicinal …, 1977 - ACS Publications
To block epimerization and the resulting biological deactivationof podophyllotoxin compounds,
the lactone carbonyl group has been changed tomethylene. Syntheses of several of …

Measurement of the Z0 Mass and Width with the OPAL Detector at LEP

…, NI Geddes, CNP Gee, C Geich-Gimbel, SW Gensler… - Physics Letters B, 1989 - Elsevier
We report an experimental determination of the cross section for e + e − → hadrons from a
scan around the Z 0 pole. On the basis of 4350 hadronic events collected over seven energy …

The Podophyllotoxin—Picropodophyllin Equilibrium1,2

WJ Gensler, CD Gatsonis - The Journal of Organic Chemistry, 1966 - ACS Publications
Podophyllotoxin and picropodophyllin dissolved in-butyl alcohol containing 0.1 M piperidine
are interconvertible. The equilibrium constants and standard free-energy changes in …

The Detector simulation program for the OPAL experiment at LEP

…, JW Gary, J Gascon, NI Geddes, SW Gensler… - Nuclear Instruments and …, 1992 - Elsevier
… to the middle of the gas cell with a 20% variation allowed from particle to particle to fit the
variation observed in w+w- events. The efficiency of the detector is adjusted to tit w+W events. …

A study of coherence of soft gluons in hadron jets

…, NI Geddes, CNP Gee, C Geich-Gimbel, SW Gensler… - Physics Letters B, 1990 - Elsevier
We study the inclusive momentum distribution of charged particles in multihadronic events
produced in e + e − annihilations at E CM ∼M(Z 0 ). We find agreement with the analytical …