The prognosis of patients with connective tissue disease (CTD) has improved significantly
in recent years, but interstitial lung disease (ILD) associated with connective tissue disease (…

Influenza is an acute respiratory disease caused by the influenza virus. The disease occurs
annually, causing fatality in the elderly and children and billions of dollars loss in business …

1, 25-Dihydroxyvitamin D3 [1, 25 (OH) 2D3; 1, 25-dihydroxycholecalciferol or calcitriol] is
the active form of vitamin D3, a lipid-soluble vitamin that plays a role in calcium and bone …

The tree of life is one of the most important organizing principles in biology 1. Gene surveys
suggest the existence of an enormous number of branches 2, but even an approximation of …

Genome editing therapy for Duchenne muscular dystrophy (DMD) holds great promise,
however, one major obstacle is delivery of the CRISPR-Cas9/sgRNA system to skeletal muscle …

Posttranslational modification can confer special functions to peptides. Based on exhaustive
liquid chromatography mass spectrometry analysis targeting tyrosine-sulfated peptides, we …

Embryogenic cells of asparagus (Asparagus officinalis L.) were successfully cryopreserved
by vitrification and subsequently regenerated plants. The cells were cryoprotected with a …

Background: aPKC and PAR-1 are required for cell polarity in various contexts. In mammalian
epithelial cells, aPKC localizes at tight junctions (TJs) and plays an indispensable role in …

Bacteriophages typically have small genomes 1 and depend on their bacterial hosts for
replication 2 . Here we sequenced DNA from diverse ecosystems and found hundreds of phage …

Hyoscyamine 6 beta-hydroxylase (H6H; EC 1.14.11.11) catalyzes the first reaction in the
biosynthetic pathway from hyoscyamine to scopolamine in several solanaceous plants. Four …