User profiles for A. Minard

Aisling Minard

Research Associate in Chemical Biology, Imperial College London
Verified email at imperial.ac.uk
Cited by 333

Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome

F Raguseo, S Chowdhury, A Minard… - Chemical …, 2020 - pubs.rsc.org
G-quadruplexes are nucleic acids secondary structures that can be formed in guanine-rich
sequences. More than 30 years ago, their formation was first observed in telomeric DNA. …

[HTML][HTML] Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease

A Minard, CC Bauer, DJ Wright, HN Rubaiy, K Muraki… - Cells, 2018 - mdpi.com
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels
permeable to Na + , K + and Ca 2+ . In this review, we focus on channels formed by the isoforms …

Humane endpoints in shock research

JA Nemzek, HY Xiao, AE Minard, GL Bolgos… - Shock, 2004 - journals.lww.com
In biomedical research using animal models, the phrase “humane endpoints” refers to
predetermined criteria used to judge when the research animals should be humanely euthanized. …

MEANTIME, the NewsReader multilingual event and time corpus

AL Minard, M Speranza, R Urizar, B Altuna… - Proceedings of the …, 2016 - aclanthology.org
In this paper, we present the NewsReader MEANTIME corpus, a semantically annotated
corpus of Wikinews articles. The corpus consists of 480 news articles, ie 120 English news …

[HTML][HTML] Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

DJ Fazakerley, AY Minard, JR Krycer… - Journal of Biological …, 2018 - ASBMB
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …

Semeval-2015 task 4: Timeline: Cross-document event ordering

ALM Minard, M Speranza, E Agirre, I Aldabe… - proceedings of the 9th …, 2015 - cris.fbk.eu
This paper describes the outcomes of the TimeLine task (Cross-Document Event Ordering),
that was organised within the Time and Space track of SemEval-2015. Given a set of …

Overview of the fifth social media mining for health applications (# smm4h) shared tasks at coling 2020

…, A Magge, Z Miftahutdinov, AL Minard… - Proceedings of the …, 2020 - aclanthology.org
The vast amount of data on social media presents significant opportunities and challenges
for utilizing it as a resource for health informatics. The fifth iteration of the Social Media Mining …

[HTML][HTML] High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

…, AL Wright, NJ Hoffman, AY Minard… - Journal of biological …, 2018 - ASBMB
Obesity is associated with metabolic dysfunction, including insulin resistance and
hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and …

The unexplored potential of quinone methides in chemical biology

A Minard, D Liano, X Wang, M Di Antonio - Bioorganic & Medicinal …, 2019 - Elsevier
Quinone methides (QMs) are transient reactive species that can be efficiently generated
from stable precursors under a variety of biocompatible conditions. Due to their electrophilic …

[HTML][HTML] Newsreader: Using knowledge resources in a cross-lingual reading machine to generate more knowledge from massive streams of news

…, M van Erp, A Fokkens, E Laparra, AL Minard… - Knowledge-Based …, 2016 - Elsevier
In this article, we describe a system that reads news articles in four different languages and
detects what happened, who is involved, where and when. This event-centric information is …