User profiles for C. Elmore

charles elmore

astrazeneca
Verified email at astrazeneca.com
Cited by 2603

[HTML][HTML] Isotope chemistry; a useful tool in the drug discovery arsenal

CS Elmore, RA Bragg - Bioorganic & medicinal chemistry letters, 2015 - Elsevier
… to minimize the amount of radioactive waste produced during a subsequent C-14 synthesis.
This work will be required prior to the C-14 synthesis, even if the SIL synthesis is outsourced, …

The use of isotopically labeled compounds in drug discovery

CS Elmore - Annual Reports in Medicinal Chemistry, 2009 - Elsevier
… This results in multiple C-14 atoms in the aromatic ring and thus multiple C-14 labels in
the target molecule. This is not generally a problem, but can complicate LC/MS analyses. …

Selective serotonin reuptake inhibitors as first‐line antidepressant therapy for perinatal depression

G Latendresse, C Elmore… - Journal of Midwifery & …, 2017 - Wiley Online Library
One in 7 women experience depression during the prenatal and/or postpartum period.
Nonpharmacologic approaches are known to be as effective as pharmacologic therapies for mild …

Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles

…, M Lerche, L Porcar, C Lang, RA Bragg, CS Elmore… - ACS …, 2021 - ACS Publications
… of ApoE were followed upon heating to 37 C, then to 49 C (in an attempt to melt the DSPC
… to 25 C (Figure SI10). MCHPC incubation with ApoE was monitored as well for 21 h at 25 C (…

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide …

…, W Tang, I McIntosh, K Leung, C Elmore… - Chemical research in …, 2001 - ACS Publications
Therapy with the oral antidiabetic agent troglitazone (Rezulin) has been associated with cases
of severe hepatotoxicity and drug-induced liver failure, which led to the recent withdrawal …

[HTML][HTML] Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease

SD Kunkel, CJ Elmore, KS Bongers, SM Ebert, DK Fox… - PloS one, 2012 - journals.plos.org
Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose
intolerance and fatty liver disease. We recently found that ursolic acid increases skeletal …

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies

EM Isin, CS Elmore, GN Nilsson… - Chemical research in …, 2012 - ACS Publications
… of 14 C from the blood when the compound was labeled with 14 C in the benzimidazole
moiety (unpublished results). The elimination appeared to follow zero order kinetics with a time …

Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] sitagliptin in humans

SH Vincent, JR Reed, AJ Bergman, CS Elmore… - Drug metabolism and …, 2007 - ASPET
The metabolism and excretion of [ 14 C]sitagliptin, an orally active, potent and selective
dipeptidyl peptidase 4 inhibitor, were investigated in humans after a single oral dose of 83 mg/…

The influence of supportive parenting and racial socialization messages on African American youth behavioral outcomes

CA Elmore, NK Gaylord-Harden - Journal of Child and Family Studies, 2013 - Springer
A warm and supportive parent–child relationship is one of the most crucial determinants of
positive outcomes in racially and socioeconomically diverse youth. There is, however, limited …

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

CL Elmore, X Wu, D Leclerc, ED Watson… - Molecular genetics and …, 2007 - Elsevier
Hyperhomocyst(e)inemia is a metabolic derangement that is linked to the distribution of folate
pools, which provide one-carbon units for biosynthesis of purines and thymidylate and for …