Maternal-infant transmission of hepatitis C virus infection

EA Roberts, L Yeung - Hepatology, 2002 - journals.lww.com
Roberts has received research grants from the Schering-Plough Research Institute and
GlaxoWellcome; she has served as a consultant to Janssen-Ortho Pharmaceuticals. Dr. Yeung …

Mother–to–infant transmission of hepatitis C virus

LTF Yeung, SM King, EA Roberts - Hepatology, 2001 - journals.lww.com
Hepatitis C virus (HCV) infection is acquired through transfusion of infected blood or blood
products or through routes not related to transfusion, classified as communityacquired disease…

Pediatric nonalcoholic fatty liver disease (NAFLD): a “growing” problem?

EA Roberts - Journal of hepatology, 2007 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) can affect both adults and children. With the current
worldwide epidemic of pediatric obesity, pediatric NAFLD is increasingly being diagnosed. …

Prediction of DNA repair inhibitor response in short-term patient-derived ovarian cancer organoids

SJ Hill, B Decker, EA Roberts, NS Horowitz, MG Muto… - Cancer discovery, 2018 - AACR
Based on genomic analysis, 50% of high-grade serous ovarian cancers (HGSC) are
predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually have …

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

…, SO Ali, R Deasy, P Keskula, RWS Ng, EA Roberts… - Nature, 2019 - nature.com
Synthetic lethality—an interaction between two genetic events through which the co-occurrence
of these two genetic events leads to cell death, but each event alone does not—can be …

A method for estimating the probability of adverse drug reactions

…, P Sandor, I Ruiz, EA Roberts… - Clinical …, 1981 - Wiley Online Library
The estimation of the probability that a drug caused an adverse clinical event is usually based
on clinical judgment. Lack of a method for establishing causality generates large between‐…

[PDF][PDF] Diagnosis and treatment of Wilson disease: an update

EA Roberts, ML Schilsky - Hepatology, 2008 - Wiley Online Library
Copper is an essential metal that is an important cofactor for many proteins. The average diet
provides substantial amounts of copper, typically 2-5 mg/day; the recommended intake is …

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice

AM Clement, MD Nguyen, EA Roberts, ML Garcia… - science, 2003 - science.org
The most common form of amyotrophic lateral sclerosis (ALS), a neurodegenerative
disease affecting adult motor neurons, is caused by dominant mutations in the ubiquitously …

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

C Liang, J Lee, KS Inn, MU Gack, Q Li, EA Roberts… - Nature cell …, 2008 - nature.com
Autophagic and endocytic pathways are tightly regulated membrane rearrangement
processes that are crucial for homeostasis, development and disease. Autophagic cargo is …

Lysosomal positioning coordinates cellular nutrient responses

…, S Saiki, M Lichtenberg, FH Siddiqi, EA Roberts… - Nature cell …, 2011 - nature.com
mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth
autophagy) regulate numerous pathological and physiological processes, including cellular …