[HTML][HTML] Aspergillus fumigatus—What Makes the Species a Ubiquitous Human Fungal Pathogen?

KJ Kwon-Chung, JA Sugui - PLoS pathogens, 2013 - journals.plos.org
Aspergillus fumigatus, the major cause of life threatening invasive aspergillosis (IA), is a
ubiquitous saprophytic fungus to which humans are exposed daily in most parts of the world. …

Aspergillus fumigatus and related species

JA Sugui, KJ Kwon-Chung… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The genus Aspergillus contains etiologic agents of aspergillosis. The clinical manifestations
of the disease range from allergic reaction to invasive pulmonary infection. Among the …

What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?

KJ Kwon-Chung, JA Sugui - Medical mycology, 2009 - Taylor & Francis
Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major
and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the …

Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone

JA Sugui, J Pardo, YC Chang, KA Zarember… - Eukaryotic …, 2007 - Am Soc Microbiol
Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence
factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, …

Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion

KA Zarember, JA Sugui, YC Chang… - The Journal of …, 2007 - journals.aai.org
Aspergillus fumigatus, a common mold, rarely infects humans, except during prolonged
neutropenia or in cases of chronic granulomatous disease (CGD), a primary immunodeficiency …

Agrobacterium tumefaciens-Mediated Transformation of Aspergillus fumigatus: an Efficient Tool for Insertional Mutagenesis and Targeted Gene Disruption

JA Sugui, YC Chang… - Applied and environmental …, 2005 - Am Soc Microbiol
Agrobacterium tumefaciens was used to transform Aspergillus fumigatus by either random
or site-directed integration of transforming DNA (T-DNA). Random mutagenesis via …

[HTML][HTML] Extrapulmonary Aspergillus infection in patients with CARD9 deficiency

…, AF Freeman, AP Hsu, AL Collar, JA Sugui… - JCI insight, 2016 - ncbi.nlm.nih.gov
Invasive pulmonary aspergillosis is a life-threatening mycosis that only affects patients with
immunosuppression, chemotherapy-induced neutropenia, transplantation, or congenital …

[HTML][HTML] Genes Differentially Expressed in Conidia and Hyphae of Aspergillus fumigatus upon Exposure to Human Neutrophils

JA Sugui, HS Kim, KA Zarember, YC Chang, JI Gallin… - PLoS …, 2008 - journals.plos.org
Background Aspergillus fumigatus is the most common etiologic agent of invasive aspergillosis
in immunocompromised patients. Several studies have addressed the mechanism …

Invasive Aspergillosis Due to Neosartorya udagawae

DC Vinh, YR Shea, JA Sugui… - Clinical infectious …, 2009 - academic.oup.com
Background . Invasive aspergillosis (IA) is most commonly caused by the morphospecies
Aspergillus fumigatus. However, genetic-based methods indicate that organisms …

Invasive fungal disease in autosomal-dominant hyper-IgE syndrome

DC Vinh, JA Sugui, AP Hsu, AF Freeman… - Journal of allergy and …, 2010 - jacionline.org
Medical records of all patients with the diagnosis of AD-HIES enrolled on protocols of the
National Institute of Allergy and Infectious Diseases, National Institutes of Health, and …