Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human
disease in relevant cell types, but it is unclear whether they could successfully model age‐…

Huntington’s disease is a neurodegenerative disorder characterized by a selective degeneration
of striatal projection neurons, which deal with choreic movements. Neuroprotective …

The implementation of neural stem cell lines as a source material for brain tissue transplants
is currently limited by the ability to induce specific neurochemical phenotypes in these cells. …

Huntington's disease is a neurodegenerative disorder characterized by the selective loss of
striatal neurons and, to a lesser extent, cortical neurons. The neurodegenerative process is …

The mechanism that controls the selective vulnerability of striatal neurons in Huntington's
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …

Neural stem cells (NSCs) have been proposed as tools for treating neurodegeneration
because of their capacity to give rise to cell types appropriate to the structure in which they are …

The aim of this paper is to study how grape ripeness and ethanol concentration affect the
extraction of color and phenolic compounds from skins and seeds during the maceration/…

The precise mechanism by which mutant huntingtin elicits its toxicity remains unknown.
However synaptic alterations and increased susceptibility to neuronal death are known …

There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine
is a candidate drug; however, the mechanisms by which it operates remain unclear. We …

There has been substantial progress in the development of regenerative medicine strategies
for CNS disorders over the last decade, with progression to early clinical studies for some …