Animal cells must regulate their biosynthetic pathways so as to produce the required amounts
of end-products without risking overproduction. Such control is particularly important in …

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …

IN 1901, AFTER STUDYING A PATIENT WITH BLACK URINE, A physician named Archibald
Garrod suggested thata single mutant gene can produce a discrete block in a biochemical …

Resident mouse peritoneal macrophages were shown to take up and degrade acetylated
125 I-labeled low density lipoprotein ( 125 I-acetyl-LDL) in vitro at rates that were 20-fold …

SPOTLIGHT Critical review thesis. Like SREBP-1a, SREBP-2 has a long transcriptional
activation domain, but it preferentially activates cholesterol synthesis (1). SREBP-1a and SREBP-…

Atherosclerotic plaques are filled with scavenger cells that have ingested large amounts of
cholesterol and have become so stuffed with cholesteryl ester that they are converted into …

… uptake of LDL, producing hypercholesterolemia and· heart attacks (Brown & Goldstein 1984).
… , while the receptor cycles back to the cell surface to bind new ligand (Brown et aI1983). …

Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process
by which selected extracellular proteins or peptides are first bound to specific cell surface …

Purpose: The development of computer‐aided diagnostic (CAD) methods for lung nodule
detection, classification, and quantitative assessment can be facilitated through a well‐…

… Here, we show that from plasma lipoproteins in animal cells (Brown and … (S1P), a
membranecleus to regulate gene transcription (Brown et al., 2000). anchored serine protease whose …