Previous studies showed a poor correlation between sarcolemmal K + currents and
cardioprotection for ATP-sensitive K + channel (K ATP ) openers. Diazoxide is a weak cardiac …

Background Among infants with isolated cleft palate, whether primary surgery at 6 months of
age is more beneficial than surgery at 12 months of age with respect to speech outcomes, …

PURPOSE: A correlation of treatment for uterine sarcoma with outcome, prognostic importance
of pathology, and clinical parameters. PATIENTS AND METHODS: One hundred forty-…

CRF 1 antagonists DMP696 and DMP904 were designed as drug development candidates
for the treatment of anxiety and depression. Both compounds display nanomolar affinity for …

… Acylation of 5b with MeO 2 C(CH 2 ) n COCl (n = 1−3) gave the corresponding amides 6a−c,
which upon deprotonation with potassium bis(trimethylsilyl)amide in THF undergoes …

… vasodilator potency determinations, extra hearts were prepared to obtain complete concentration
responses: 0.03, and 0.1 μM concentrations were added as necessary for each drug (n …

The activation of endothelial cells by endothelium-dependent vasodilators has been
investigated using bioassay, patch clamp and 45 Ca flux methods. Cultured pulmonary artery …

… Concentration-response curve of BL-1249 for the inhibition of 30 mM KCl-induced contraction
of rat bladder and aortic strips (n = 3–12). Data shown as mean ± SEM Bladder EC 50 = …

Major depressive disorder is highly prevalent and remains inadequately treated. Numerous
studies have demonstrated that modulation of ion channel activity can reduce depression-…

… On the basis of the SAR previously developed for N 3 -phenyl pyrazinones, (33) we focused
… All values are the average of at least n = 3 ± standard deviation. The IC 50 of o-CRF = 2.9 ± …