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Research Note

Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation

Takeshi Sugiyama, Masanori Kitamura, Kanji Sugita, Tohru Okuda, Masashi Hisamoto, Atsuhito Nakao
Am J Enol Vitic. March 2013 64: 146-151; published ahead of print October 22, 2012 ; DOI: 10.5344/ajev.2012.11131
Takeshi Sugiyama
1Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
2Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
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  • For correspondence: sugiyat@yamanashi.ac.jp
Masanori Kitamura
3Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
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Kanji Sugita
2Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
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Tohru Okuda
4The Institute of Enology and Viticulture, University of Yamanashi, 13-1, Kitashin 1, Kofu, Yamanashi 400-0005, Japan
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Masashi Hisamoto
4The Institute of Enology and Viticulture, University of Yamanashi, 13-1, Kitashin 1, Kofu, Yamanashi 400-0005, Japan
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Atsuhito Nakao
1Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
5Atopy Research Center, Juntendo University School of Medicine, Tokyo 113-8421, Japan
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Abstract

The aryl hydrocarbon receptor (AhR) pathway is now considered an important pharmacological target for many human diseases. This study examined the effects of grape seed extract (GSE) obtained from the Koshu grape variety on AhR activity. The Koshu-derived GSE inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation in vivo and in vitro. These results suggest that Koshu GSE has an antagonistic effect on TCDD-induced AhR activation. Furthermore, gavage administration of TCDD resulted in the elevation of liver function, but administration of Koshu GSE together with TCDD did not elevate serum aspartate aminotransaminase (AST) and alanine transaminase (ALT) levels. These results suggest that Koshu GSE may have the potential to prevent liver disorders.

  • Koshu
  • grape seed extract
  • aryl hydrocarbon receptor
  • TCDD
  • DRESSA
  • hepatic disorder
  • ©2013 by the American Society for Enology and Viticulture
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Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation
Takeshi Sugiyama, Masanori Kitamura, Kanji Sugita, Tohru Okuda, Masashi Hisamoto, Atsuhito Nakao
Am J Enol Vitic.  March 2013  64: 146-151;  published ahead of print October 22, 2012 ; DOI: 10.5344/ajev.2012.11131

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Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation
Takeshi Sugiyama, Masanori Kitamura, Kanji Sugita, Tohru Okuda, Masashi Hisamoto, Atsuhito Nakao
Am J Enol Vitic.  March 2013  64: 146-151;  published ahead of print October 22, 2012 ; DOI: 10.5344/ajev.2012.11131
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