PT  - JOURNAL ARTICLE
AU  - Peter Winterhalter
TI  - ASEV Honorary Research Lecture 2008
AID  - 10.5344/ajev.2009.60.2.123
DP  - 2009 Jun 01
TA  - American Journal of Enology and Viticulture
PG  - 123--129
VI  - 60
IP  - 2
4099  - http://www.ajevonline.org/content/60/2/123.short
4100  - http://www.ajevonline.org/content/60/2/123.full
SO  - Am J Enol Vitic.2009 Jun 01; 60
AB  - One of the few liquid chromatographic techniques that can be predictably scaled up from analytical to process scale is countercurrent chromatography (CCC). Countercurrent chromatography furthermore enables a 100% recovery of the sample and, because of its gentle separation conditions, is ideally suited to the analysis of various groups of wine constituents. In this review, CCC instrumentation and its application to the analysis of labile wine aroma precursors, antioxidants, and pigments are examined. Moreover, novel centrifugal precipitation chromatography instrumentation for the fractionation of polymeric wine constituents and the scale-up of the technique for separations in the 10 to 100 g range are described.