TY - JOUR T1 - ASEV Honorary Research Lecture 2008 JF - American Journal of Enology and Viticulture JO - Am J Enol Vitic. SP - 123 LP - 129 DO - 10.5344/ajev.2009.60.2.123 VL - 60 IS - 2 AU - Peter Winterhalter Y1 - 2009/06/01 UR - http://www.ajevonline.org/content/60/2/123.abstract N2 - One of the few liquid chromatographic techniques that can be predictably scaled up from analytical to process scale is countercurrent chromatography (CCC). Countercurrent chromatography furthermore enables a 100% recovery of the sample and, because of its gentle separation conditions, is ideally suited to the analysis of various groups of wine constituents. In this review, CCC instrumentation and its application to the analysis of labile wine aroma precursors, antioxidants, and pigments are examined. Moreover, novel centrifugal precipitation chromatography instrumentation for the fractionation of polymeric wine constituents and the scale-up of the technique for separations in the 10 to 100 g range are described. ER -