TY - JOUR T1 - Effect of Intraperitoneal Injections of 5-Ethoxydihydro-2(3H)-Furanone and Ethanol on Behavior of Rats in the Open Field JF - American Journal of Enology and Viticulture JO - Am J Enol Vitic. SP - 121 LP - 123 DO - 10.5344/ajev.1972.23.3.121 VL - 23 IS - 3 AU - A. D. Webb AU - C. J. Muller AU - R. E. Kepner AU - K. Eriksson AU - M. NÄRHI Y1 - 1972/01/01 UR - http://www.ajevonline.org/content/23/3/121.abstract N2 - 5-Ethoxydihydro-2(3H)-furanone (4-ethoxy-4-hydroxybutyric acid gamma lactone), a trace component recently isolated from wines, when injected intraperitoneally in rats depressed ambulation, rearing, and defecation in the open-field test. Ethanol injected in conjunction with this ethoxy furanone intensified depression of ambulation. The furanone was lethal at about 600 mg/kg (IP in rats), and ethanol shortened time to death. This ethoxy furanone decomposes at pH 2 - 3; thus passage through the stomach renders it harmless to man. ER -