PT - JOURNAL ARTICLE AU - A. D. Webb AU - C. J. Muller AU - R. E. Kepner AU - K. Eriksson AU - M. NÄRHI TI - Effect of Intraperitoneal Injections of 5-Ethoxydihydro-2(3H)-Furanone and Ethanol on Behavior of Rats in the Open Field AID - 10.5344/ajev.1972.23.3.121 DP - 1972 Jan 01 TA - American Journal of Enology and Viticulture PG - 121--123 VI - 23 IP - 3 4099 - http://www.ajevonline.org/content/23/3/121.short 4100 - http://www.ajevonline.org/content/23/3/121.full SO - Am J Enol Vitic.1972 Jan 01; 23 AB - 5-Ethoxydihydro-2(3H)-furanone (4-ethoxy-4-hydroxybutyric acid gamma lactone), a trace component recently isolated from wines, when injected intraperitoneally in rats depressed ambulation, rearing, and defecation in the open-field test. Ethanol injected in conjunction with this ethoxy furanone intensified depression of ambulation. The furanone was lethal at about 600 mg/kg (IP in rats), and ethanol shortened time to death. This ethoxy furanone decomposes at pH 2 - 3; thus passage through the stomach renders it harmless to man.