PT  - JOURNAL ARTICLE
AU  - Webb, A. D.
AU  - Muller, C. J.
AU  - Kepner, R. E.
AU  - Eriksson, K.
AU  - NÄRHI, M.
TI  - Effect of Intraperitoneal Injections of 5-Ethoxydihydro-2(3H)-Furanone and Ethanol on Behavior of Rats in the Open Field
DP  - 1972 Jan 01
TA  - American Journal of Enology and Viticulture
PG  - 121--123
VI  - 23
IP  - 3
4099  - http://www.ajevonline.org/content/23/3/121.short
4100  - http://www.ajevonline.org/content/23/3/121.full
SO  - Am. J. Enol. Vitic.1972 Jan 01; 23
AB  - 5-Ethoxydihydro-2(3H)-furanone (4-ethoxy-4-hydroxybutyric acid gamma lactone), a trace component recently isolated from wines, when injected intraperitoneally in rats depressed ambulation, rearing, and defecation in the open-field test. Ethanol injected in conjunction with this ethoxy furanone intensified depression of ambulation. The furanone was lethal at about 600 mg/kg (IP in rats), and ethanol shortened time to death. This ethoxy furanone decomposes at pH 2 - 3; thus passage through the stomach renders it harmless to man.