RT Journal Article
SR Electronic
T1 Effect of Intraperitoneal Injections of 5-Ethoxydihydro-2(3H)-Furanone and Ethanol on Behavior of Rats in the Open Field
JF American Journal of Enology and Viticulture
JO Am. J. Enol. Vitic.
FD American Society for Enology and Viticulture
SP 121
OP 123
VO 23
IS 3
A1 Webb, A. D.
A1 Muller, C. J.
A1 Kepner, R. E.
A1 Eriksson, K.
A1 NÄRHI, M.
YR 1972
UL http://www.ajevonline.org/content/23/3/121.abstract
AB 5-Ethoxydihydro-2(3H)-furanone (4-ethoxy-4-hydroxybutyric acid gamma lactone), a trace component recently isolated from wines, when injected intraperitoneally in rats depressed ambulation, rearing, and defecation in the open-field test. Ethanol injected in conjunction with this ethoxy furanone intensified depression of ambulation. The furanone was lethal at about 600 mg/kg (IP in rats), and ethanol shortened time to death. This ethoxy furanone decomposes at pH 2 - 3; thus passage through the stomach renders it harmless to man.