Abstract
Objective:
To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women.
Design, subjects and intervention:
A randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks.
Setting:
Clinic in the School of Public Health, Curtin University.
Results:
There were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (−9%, P=0.02) and AP (−12%, P=0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water.
Conclusions:
Neither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation.
Sponsorship:
Curtin University and National Heart Foundation of Australia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Aviram M, Dornfeld L (2001). Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158, 195–198.
Benetos A, Gautier S, Ricard S, Topouchian J, Asmar R, Poirier O et al. (1996). Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation 94, 698–703.
Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R (2002). Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol 282, H942–H948.
Borghi C, Dormi A, L'Italien G, Lapuerta P, Franklin SS, Collatina S et al. (2003). The relationship between systolic blood pressure and cardiovascular risk – results of the Brisighella Heart Study. J Clin Hypertens (Greenwich) 5, 47–52.
Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P et al. (2002). Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 39, 10–15.
Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL et al. (1997). Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation 95, 1827–1836.
Chen CK, Pace-Asciak CR (1996). Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 27, 363–366.
Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG et al. (2001). Endothelin-1 synthesis reduced by red wine. Nature 414, 863–864.
Dell'Agli M, Galli GV, Vrhovsek U, Mattivi F, Bosisio E (2005). In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes. J Agric Food Chem 53, 1960–1965.
Diebolt M, Bucher B, Andriantsitohaina R (2001). Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension 38, 159–165.
Estruch R, Sacanella E, Badia E, Antunez E, Nicolas JM, Fernandez-Sola J et al. (2004). Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 175, 117–123.
Goldberg DM, Garovic-Kocic V, Diamandis EP, Pace-Asciak CR (1996). Wine: Does the colour count? Clinica Chimica Acta 246, 183–193.
Gonzalez MA, Selwyn AP (2003). Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 115 (Suppl 8A), 99S–106S.
Helrick K (1990). Official methods of analysis of the Association of Official Analytical Chemists. AOAC: Arlington, VA.
Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007–1011.
Kampus P, Kals J, Ristimae T, Fischer K, Zilmer M, Teesalu R (2004). High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons. J Hypertens 22, 1133–1139.
Khan NQ, Lees DM, Douthwaite JA, Carrier MJ, Corder R (2002). Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells. Clin Sci (London) 103 (Suppl 48), 72S–75S.
Kingwell BA, Gatzka CD (2002). Arterial stiffness and prediction of cardiovascular risk. J Hypertens 20, 2337–2340.
Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L et al. (2001). Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37, 1236–1241.
Mahmud A, Feely J (2002). Divergent effect of acute and chronic alcohol on arterial stiffness. Am J Hypertens 15, 240–243.
McEniery CM, Qasem A, Schmitt M, Avolio AP, Cockcroft JR, Wilkinson IB (2003). Endothelin-1 regulates arterial pulse wave velocity in vivo. J Am Coll Cardiol 42, 1975–1981.
Meredith IT, Anderson TJ, Uehata A, Yeung AC, Selwyn AP, Ganz P (1993). Role of endothelium in ischemic coronary syndromes. Am J Cardiol 72, 27C–31C; discussion 31C–32C.
Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD et al. (1999). Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 84, 895–898.
Nigam A, Mitchell GF, Lambert J, Tardif JC (2003). Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease. Am J Cardiol 92, 395–399.
Nurnberger J, Keflioglu-Scheiber A, Opazo Saez AM, Wenzel RR, Philipp T, Schafers RF (2002). Augmentation index is associated with cardiovascular risk. J Hypertens 20, 2407–2414.
O'Rourke M (1990). Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. Hypertension 15, 339–347.
Pirro M, Schillaci G, Savarese G, Gemelli F, Mannarino MR, Siepi D et al. (2004). Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia. Eur J Cardiovasc Prev Rehabil 11, 497–502.
Ralay Ranaivo H, Diebolt M, Andriantsitohaina R (2004). Wine polyphenols induce hypotension, and decrease cardiac reactivity and infarct size in rats: involvement of nitric oxide. Br J Pharmacol 142, 671–678.
Renaud S, De Lorgeril M, Salen MD, Martin J, Mamelle N, Monjaud I et al. (1992). Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.
Sato H, Hayashi J, Harashima K, Shimazu H, Kitamoto K (2005). A population-based study of arterial stiffness index in relation to cardiovascular risk factors. J Atheroscler Thromb 12, 175–180.
St Leger AS, Cochrane AL, Moore F (1979). Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1, 1017–1020.
Teede HJ, McGrath BP, DeSilva L, Cehun M, Fassoulakis A, Nestel PJ (2003). Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol 23, 1066–1071.
Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM (2002). Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med 9, 77–79.
Wilkinson IB, MacCallum H, Cockcroft JR, Webb DJ (2002). Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol 53, 189–192.
Yufu K, Takahashi N, Anan F, Hara M, Yoshimatsu H, Saikawa T (2004). Brachial arterial stiffness predicts coronary atherosclerosis in patients at risk for cardiovascular diseases. Jpn Heart J 45, 231–242.
Acknowledgements
The project was supported by Grants from the National Heart Foundation of Australia. We are grateful to the Chemistry Centre, Perth, Australia for the dealcoholising of red wine.
Author information
Authors and Affiliations
Corresponding author
Additional information
Guarantors: M Naissides and S Pal.
Contributors: MN, SP, JM and AJ participated in the conception and design of the study, in the analysis and interpretation of the data and preparing the manuscript. MN was responsible for implementing and coordinating the clinical trials, monitoring compliance of participants, collection of data and completion of experimental work. SD was responsible for the statistical analysis.
Rights and permissions
About this article
Cite this article
Naissides, M., Pal, S., Mamo, J. et al. The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women. Eur J Clin Nutr 60, 740–745 (2006). https://doi.org/10.1038/sj.ejcn.1602377
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejcn.1602377
Keywords
This article is cited by
-
Effects of Alcohol Reduction Interventions on Blood Pressure
Current Hypertension Reports (2022)
-
Do grape polyphenols improve metabolic syndrome components? A systematic review
European Journal of Clinical Nutrition (2017)
-
Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection
In Vitro Cellular & Developmental Biology - Animal (2008)