A three-dimensional human neural cell culture model of Alzheimer's disease

…, S Lee, C D'Avanzo, H Chen, B Hooli, C Asselin… - Nature, 2014 - nature.com
… of 20 μl under the following conditions: 95 C for 15 min, and then 30 cycles at 94 C for 30 s,
60 C for 30 s and 74 C for 90 s with a final 10 min extension at 74 C. RT–PCR products were …

[PDF][PDF] Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

…, AR Parrado, AN Lesinski, CN Asselin… - Neuron, 2013 - cell.com
The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that
regulates innate immunity but has no known functions in the brain. We have previously shown …

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model

…, A Rompala, MK Oram, C Asselin, J Aronson, C Zhang… - Science, 2018 - science.org
… (C) Schematic of RAM task and mean error number in training trials (left graph). Two-way
ANOVA with repeated measures revealed significant effects for days (F (4,164) = 99.29, P < …

[HTML][HTML] TIRAP, TRAM, and toll-like receptors: The untold story

V Lannoy, A Côté-Biron, C Asselin… - Mediators of …, 2023 - hindawi.com
Toll-like receptors (TLRs) are the most studied receptors among the pattern recognition
receptors (PRRs). They act as microbial sensors, playing major roles in the regulation of the …

Comparison of three sensory methods for use with the Napping® procedure: Case of ten wines from Loire valley

L Perrin, R Symoneaux, I Maître, C Asselin… - Food Quality and …, 2008 - Elsevier
… Bottles were stored at 11 C. Samples (about 50 mL) were presented in clear INAO wine
glasses (… conditions, in isolated booths, under white light and at room temperature (about 20 C). …

MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination.

SA Bossone, C Asselin, AJ Patel… - Proceedings of the …, 1992 - National Acad Sciences
ME1a1, a 16-base-pair nuclear factor binding site residing between the c-MYC P1 and P2
transcription initiation sites, is required for P2 activity. A cDNA encoding a 477-amino acid zinc …

[HTML][HTML] Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2

M Houde, P Laprise, D Jean, M Blais, C Asselin… - Journal of Biological …, 2001 - ASBMB
The intracellular signaling pathways responsible for cell cycle arrest and differentiation
along the crypt-villus axis of the human small intestine remain largely unknown. p38 mitogen-…

Transforming Growth Factor- β1 Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting …

…, T Muanza, R Begin, F Boudreau, C Asselin… - American Journal of …, 1997 - atsjournals.org
Glutathione (GSH) is an essential antioxidant tripeptide that protects mammalian cells against
oxidants and xenobiotics. Patients with fibrotic lung disorders have very low levels of GSH …

[HTML][HTML] Phosphatases in toll-like receptors signaling: the unfairly-forgotten

V Lannoy, A Côté-Biron, C Asselin, N Rivard - Cell Communication and …, 2021 - Springer
Over the past 2 decades, pattern recognition receptors (PRRs) have been shown to be on
the front line of many illnesses such as autoimmune, inflammatory, and neurodegenerative …

Constitutively active MEK1 is sufficient to induce epithelial‐to‐mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

…, V Durand, C Asselin, C Saucier… - … journal of cancer, 2009 - Wiley Online Library
… Parameters for DNA amplification were 94C for 45 sec, annealing temperature (59C) for
30 sec and 72C for 45 sec. Oligonucleotide primers used for DNA amplification were …