The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

… Rossi, McBride, and Chang are employees and stockholders of Immunomedics and/or IBC
… Sharkey RM, Cardillo TM, Rossi EA, et al. Signal amplification in molecular imaging by …

The use of antibodies against tumor-associated cell surface antigens for the targeted delivery
of radionuclides was introduced >20 years ago. Although encouraging results have been …

Small biomolecules are typically radiolabeled with 18 F by binding it to a carbon atom, a
process that usually is designed uniquely for each new molecule and requires several steps …

Trop-2 is a novel target for ADC therapy because of its high expression by many solid cancers.
The rational development of IMMU-132 represents a paradigm shift as an ADC that binds …

Visual resolution decreases rapidly outside of the foveal center. The anatomical and physiological
basis for this reduction is unclear. We used simultaneous adaptive optics imaging and …

We describe a platform technology, termed the dock and lock method, which uses a natural
binding between the regulatory subunits of cAMP-dependent protein kinase and the …

Sacituzumab govitecan (IMMU-132) is an antibody–drug conjugate (ADC) made from a
humanized anti-Trop-2 monoclonal antibody (hRS7) conjugated with the active metabolite of …

We reported previously the feasibility to radiolabel peptides with fluorine-18 ( 18 F) using a
rapid one-pot method that first mixes 18 F − with Al 3+ and then binds the (Al 18 F) 2+ …

Although imaging of the living retina with adaptive optics scanning light ophthalmoscopy (AOSLO)
provides microscopic access to individual cells, such as photoreceptors, retinal …