Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment

…, F Remiao, ML Bastos, F Carvalho - Critical reviews in …, 2008 - Taylor & Francis
Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …

Paraquat exposure as an etiological factor of Parkinson's disease

RJ Dinis-Oliveira, F Remiao, H Carmo, JA Duarte… - Neurotoxicology, 2006 - Elsevier
Parkinson's disease (PD) is a multifactorial chronic progressive neurodegenerative disease
influenced by age, and by genetic and environmental factors. The role of genetic …

Toxicity of amphetamines: an update

…, JP Capela, H Pontes, F Remião, F Carvalho… - Archives of …, 2012 - Springer
Amphetamines represent a class of psychotropic compounds, widely abused for their
stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and …

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

…, F Carvalho, M de Lourdes Bastos, F Remiao - Pharmacology & …, 2015 - Elsevier
P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1 gene in humans,
known to mediate multidrug resistance of neoplastic cells to cancer therapy. For several …

Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview

…, F Remião, ML Bastos, A Meisel, F Carvalho - Molecular …, 2009 - Springer
“Ecstasy” [(±)-3,4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a psychoactive
recreational hallucinogenic substance and a major worldwide drug of abuse. Several reports …

[HTML][HTML] Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination

…, L Javorská, J Pourová, L Mercolini, F Remião… - Nutrients, 2021 - mdpi.com
Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its
physiological role is much larger and encompasses very different processes ranging from …

[HTML][HTML] Molecular mechanisms of ferroptosis and their involvement in brain diseases

…, V Silva, D Chavarria, F Borges, F Remião… - Pharmacology & …, 2023 - Elsevier
Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of iron
and reactive oxygen species, inhibition of system Xc-, glutathione depletion, nicotinamide …

Collection of biological samples in forensic toxicology

…, F Carvalho, JA Duarte, F Remiao… - Toxicology …, 2010 - Taylor & Francis
Forensic toxicology is the study and practice of the application of toxicology to the purposes
of the law. The relevance of any finding is determined, in the first instance, by the nature and …

Vitamin K–sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity

…, K Mrštná, A Carazo, M Protti, F Remião… - Nutrition …, 2022 - academic.oup.com
Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also involved in …

[HTML][HTML] Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

…, L Javorská, K Macáková, L Mercolini, F Remião… - Nutrients, 2022 - mdpi.com
This review summarizes the current knowledge on essential vitamins B 1 , B 2 , B 3 , and B
5 . These B-complex vitamins must be taken from diet, with the exception of vitamin B 3 , that …