DTS-108, A Novel Peptidic Prodrug of SN38: In vivo Efficacy and Toxicokinetic Studies

F Meyer-Losic, C Nicolazzi, J Quinonero, F Ribes… - Clinical Cancer …, 2008 - AACR
Purpose: Irinotecan is a prodrug converted to the active cytotoxic molecule SN38 predominantly
by the action of liver carboxylesterases. The efficacy of irinotecan is limited by this …

Influence of ethylene on sucrose accumulation in grape berry

…, N Terrier, A Ageorges, F Ribes… - … Journal of Enology …, 2006 - Am Soc Enol Viticulture
Grape ripening is thought to be ethylene independent. However, Cabernet Sauvignon berries
that were treated with 1-methylcyclopropene, a specific inhibitor of ethylene receptors, …

Substrate activation in acetylcholinesterase induced by low pH or mutation in the π-cation subsite

…, LM Schopfer, CF Bartels, MT Froment, F Ribes… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Substrate inhibition is considered a defining property of acetylcholinesterase (AChE), whereas
substrate activation is characteristic of butyrylcholinesterase (BuChE). To understand the …

Preclinical toxicity, toxicokinetics, and antitumoral efficacy studies of DTS-201, a tumor-selective peptidic prodrug of doxorubicin

…, JP Delord, P Rochaix, C Nicolazzi, F Ribes… - Clinical cancer …, 2008 - AACR
Purpose: There is a clear clinical need for cytotoxic drugs with a lower systemic toxicity. DTS-201
(CPI-0004Na) is a peptidic prodrug of doxorubicin that shows an improved therapeutic …

High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine

…, CF Bartels, MT Froment, F Ribes… - European journal of …, 2003 - Wiley Online Library
Butyrylcholinesterase is a serine esterase, closely related to acetylcholinesterase. Both
enzymes employ a catalytic triad mechanism for catalysis, similar to that used by serine …

Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior

P Masson, MT Froment, S Fort, F Ribes, N Bec… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Hydrolysis of the neutral substrate N-methylindoxyl acetate (NMIA) by wild-type human
butyrylcholinesterase (BuChE) and peripheral site mutants (D70G, Y332A, D70G/Y332A) was …

Capillary zone electrophoresis with optimized temperature control for studying thermal denaturation of proteins at various pH

D Rochu, G Ducret, F Ribes, S Vanin… - ELECTROPHORESIS …, 1999 - Wiley Online Library
Capillary electrophoresis (CE) was used to analyze the thermal denaturation of bovine β‐lactoglobulin
at different pH. This model protein exhibits complex pH‐ and temperature …

Pressure-and heat-induced inactivation of butyrylcholinesterase: evidence for multiple intermediates and the remnant inactivation process

A Weingand-Ziadé, F Ribes, F Renault… - Biochemical …, 2001 - portlandpress.com
The inactivation process of native (N) human butyrylcholinesterase (BuChE) by pressure
and/or heat was found to be multi-step. It led to irreversible formation of an active intermediate (I…

[HTML][HTML] Electrocardiographic abnormalities in COVID-19 patients visiting the emergency department: a multicenter retrospective study

…, D Therasse, M Trotignon, F Arabucki, S Ribes… - BMC Emergency …, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
associated with myocardial injury. Identification of at-risk patients and mechanisms underlying …

Évaluation du fixateur externe péri-articulaire dans les fractures du pilon tibial: série rétrospective de 47 cas

…, M Garcia, P Meynard, A Cadennes, C Ribes… - Revue de Chirurgie …, 2022 - Elsevier
Introduction Les fractures du pilon tibial demeurent un challenge thérapeutique sans réel
traitement de référence avec des complications cutanées qui font leur gravité. La fixation …