The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

O 6 -methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense
against alkylating agents that generate, among other lesions, O 6 -alkylguanine in DNA (…

… In recent years, the Christmann group has worked in the field of dienamine catalysis. In
2008, they reported on the synthesis of novel mono- and bicyclic scaffolds by γ-activation of …

Introduction: The aim of this study was to assess for the first time the prevalence and factors
associated with stimulant use exclusively for cognitive enhancement among pupils and …

O 6 -Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-mutagenic,
pre-carcinogenic and pre-toxic DNA damage O 6 -methylguanine. It also …

Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were
exposed to genotoxicants. The types of DNA damage triggering these responses and their …

DNA repair is the first barrier in the defense against genotoxic stress. In recent years, mechanisms
that recognize DNA damage and activate DNA repair functions through transcriptional …

All in one: A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see
structure) by using an “uninterrupted sequence of reactions” has been developed. This …

… value of 9.5 nM. c) Mean responses after 4 min exposure to vehicle, 1 μM (−)-EA, or 1 μM
(+)… min exposure to vehicle, 1 μM (−)-EA, or 1 μM (−)-EA in the presence of 5 μM ML204 (n/N=4/…

Monocytes are key players in the immune system. Crossing the blood barrier, they infiltrate
tissues and differentiate into (i) macrophages that fight off pathogens and (ii) dendritic cells (…