The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5 + stem cells at the bottoms of …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently
believed that four to six crypt stem cells reside at the +4 position immediately above the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …

Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive
formation of nuclear ß-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf …

The study of gastric epithelial homeostasis and cancer has been hampered by the lack of
stem cell markers and in vitro culture methods. The Wnt target gene Lgr5 marks stem cells in …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …

M. tuberculosis and M. leprae are considered to be prototypical intracellular pathogens that
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …

Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction
with target cells (TC). In this process, the granule contents, including the lethal protein …

Ultrasonography has proved a valuable tool for the detection of enlarged lymph nodes;
however, differentiation between benign and malignant nodal disease remains a problem. High-…

The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative
cells are confined to crypts, while differentiated cell types predominantly occupy the villi. …