User profiles for Roberto Chignola

Roberto Chignola

Department of Biotechnology
Verified email at univr.it
Cited by 1970

Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction

…, M Fusi, A Peruffo, C Rizzi, R Chignola - Toxicology and applied …, 2009 - Elsevier
Wheat germ agglutinin (WGA) is a plant protein that binds specifically to sugars expressed,
among many others, by human gastrointestinal epithelial and immune cells. WGA is a toxic …

Forecasting the growth of multicell tumour spheroids: implications for the dynamic growth of solid tumours

R Chignola, A Schenetti, G Andrighetto… - Cell …, 2000 - Wiley Online Library
The growth dynamics of multicell tumour spheroids (MTS) were analysed by means of
mathematical techniques derived from signal processing theory. Volume vs. time trajectories of …

[HTML][HTML] The control of acidity in tumor cells: A biophysical model

N Piasentin, E Milotti, R Chignola - Scientific reports, 2020 - nature.com
Acidosis of the tumor microenvironment leads to cancer invasion, progression and resistance
to therapies. We present a biophysical model that describes how tumor cells regulate …

Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis

…, A Peruffo, G Andrighetto, C Rizzi, R Chignola - Cancer Letters, 2005 - Elsevier
A phenolic fraction purified form defatted seeds of Oenothera biennis promoted selective
apoptosis of human and mouse bone marrow-derived cell lines following first-order kinetics …

Effects of microencapsulation by ionic gelation on the oxidative stability of flaxseed oil

A Menin, F Zanoni, M Vakarelova, R Chignola, G Donà… - Food Chemistry, 2018 - Elsevier
Flaxseed oil is a major source of omega-3 polyunsaturated fatty acids (PUFAs), as it
contains nearly 50% of alpha-linolenic acid. For this reason it is highly susceptible to auto-oxidation. …

Development of a new procedure for protein recovery and quantification in wine

…, G Veneri, R Chignola… - … Journal of Enology …, 2005 - Am Soc Enol Viticulture
In order to develop a procedure for protein recovery and quantification in wines, known
amounts of bovine serum albumin (BSA) were added to samples of protein-free wine. Dialysis …

Production of stable food-grade microencapsulated astaxanthin by vibrating nozzle technology

…, F Zanoni, P Lardo, G Rossin, F Mainente, R Chignola… - Food chemistry, 2017 - Elsevier
Astaxanthin is a carotenoid known for its strong antioxidant and health-promoting
characteristics, but it is also highly degradable and thus unsuited for several applications. We …

Planar AFM macro-probes to study the biomechanical properties of large cells and 3D cell spheroids

L Andolfi, SLM Greco, D Tierno, R Chignola… - Acta biomaterialia, 2019 - Elsevier
The ability to measure mechanical response of cells under applied load is essential for
developing more accurate models of cell mechanics and mechanotransduction. Living cells have …

[HTML][HTML] Emergent properties of tumor microenvironment in a real-life model of multicell tumor spheroids

E Milotti, R Chignola - PloS one, 2010 - journals.plos.org
Multicellular tumor spheroids are an important in vitro model of the pre-vascular phase of
solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of …

Plant lectins as carriers for oral drugs: is wheat germ agglutinin a suitable candidate?

…, S Mosconi, G Zoccatelli, A Peruffo, R Chignola - Toxicology and applied …, 2005 - Elsevier
Wheat germ agglutinin (WGA) is a plant protein that binds specifically to sugars expressed
also by gastrointestinal epithelial cells. WGA is currently investigated as an anti-tumor drug …